In addition, Li et al. have revealed the upregulation of PI3K/AKT pathway encourages the expressions of placental growth component (PlGF) and C-X-C Motif Chemokine Ligand one (CXCL1) in lung most cancers stem cells, which more encourage angiogenesis [59]. CCPlenty of paracrine elements secreted by MSCs are ligands for receptors that activate PI3K/A

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